Protein Details: Aquaporin-5

Protein ID

ICDB_Pro_0619

Protein Name

Aquaporin-5

Gene Name

AQP5

Organism

Homo sapiens (Human)

Length

265 amino acids

AlphaFoldDB

AF-P55064-F1-model_v4.pdb

Function

Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4;controls regulatory volume decrease in salivary epithelial cells . Seems to play a redundant role in water transport in the eye;lung and in sweat glands (By similarity).

Sequence

MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR

PDB Structures

3D9S 5C5X 5DYE 7STC

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Palmoplantar Keratoderma;Bothnian Type and Pachyonychia Congenita 1

Location

Detected in skin eccrine sweat glands;at the apical cell membrane and at intercellular canaliculi (at protein level)

DOI ID

10.1074/jbc.271.15.8599; 10.1101/gr.2596504; 10.1074/jbc.m600549200; 10.1016/j.jdermsci.2013.01.013; 10.1073/pnas.0801466105; 10.1371/journal.pone.0143027; 10.1016/j.ajhg.2013.06.008

RefSeq

NP_001642.1